EWING, N.J. (AP) ? Frontier Airlines will suspend all flights at Trenton-Mercer Airport this fall while runway work is completed.
The airline announced Friday that the gap in service will last from Sept. 9 through Nov. 7.
During that time, the airport will upgrade its main runway with safety enhancements mandated by the Federal Aviation Administration.
Frontier recently announced that the planned shutdown of Trenton-Mercer Airport's air traffic control tower due to federal budget cuts won't affect service.
The airline is scheduled to begin service to Atlanta, Chicago-Midway, Columbus, Ohio, Detroit and Raleigh, N.C. next month. Frontier already flies between Trenton-Mercer and New Orleans, Fort Myers, Fort Lauderdale, Orlando and Tampa, Fla.
The field of regenerative medicine holds great promise, propelled by greater understanding of how stem cells differentiate themselves into many of the body's different cell types. But clinical applications in the field have been slow to materialize, partially owing to difficulties in replicating the conditions these cells naturally experience.
A team of researchers from the University of Pennsylvania has generated new insight on how a stem cell's environment influences what type of cell a stem cell will become. They have shown that whether human mesenchymal stem cells turn into fat or bone cells depends partially on how well they can "grip" the material they are growing in.
The research was conducted by graduate student Sudhir Khetan and associate professor Jason Burdick, along with professor Christopher Chen, all of the School of Engineering and Applied Science's Department of Bioengineering. Others involved in the study include Murat Guvendiren, Wesley Legant and Daniel Cohen.
Their study was published in the journalNature Materials.
Much research has been done on how stem cells grow on two-dimensional substrates, but comparatively little work has been done in three dimensions. Three-dimensional environments, or matrices, for stems cells have mostly been treated as simple scaffolding, rather than as a signal that influences the cells' development.
Burdick and his colleagues were interested in how these three-dimensional matrices impact mechanotransduction, which is how the cell takes information about its physical environment and translates that to chemical signaling.
"We're trying to understand how material signals can dictate stem cell response," Burdick said. "Rather than considering the material as an inert structure, it's really guiding stem cell fate and differentiation ? what kind of cells they will turn into."
The mesenchymal stem cells the researchers studied are found in bone marrow and can develop into several cell types: osteoblasts, which are found in bone; chondrocytes, which are found in cartilage; and adipocytes, which are found in fat.
The researchers cultured them in water-swollen polymer networks known as hydrogels, which share some similarities with the environments stem cells naturally grow in. These materials are generally soft and flexible ? contact lenses, for example, are a type of hydrogel ? but can vary in density and stiffness depending on the type and quantity of the bonds between the polymers. In this case, the researchers used covalently cross-linked gels, which contain irreversible chemical bonds.
When seeded on top of two-dimensional covalently cross-linked gels, mesenchymal stem cells spread and pulled on the material differently depending on how stiff it was. Critically, the mechanics guide cell fate, or the type of cells they differentiate it into. A softer environment would produce more fat-like cells and a stiffer environment, where the cells can pull on the gel harder, would produce more bone-like cells.
However, when the researchers put mesenchymal stem cells inside three-dimensional hydrogels of varying stiffness, they didn't see these kinds of changes.
"In most covalently cross-linked gels, the cells can't spread into the matrix because they can't degrade the bonds ? they all become fat cells," Burdick said. "That tells us that in 3D covalent gels the cells don't translate the mechanical information the same way they do in a 2D system."
To test this, the researchers changed the chemistry of their hydrogels so that the polymer chains were connected by a peptide that the cells could naturally degrade. They hypothesized that, as the cells spread, they would be able to get a better grip on their surrounding environment and thus be more likely to turn into bone-like cells.
In order to determine how well the cells were pulling on their environment, the researchers used a technique developed by Chen's lab called 3D traction force microscopy. This technique involves seeding the gel with microscopic beads, then tracking their location before and after a cell is removed.
"Because the gel is elastic and will relax back into its original position when you remove the cells," Chen said, "you can quantify how much the cells are pulling on the gel based on how much and which way it springs back after the cell is removed."
The results showed that the stem cells' differentiation into bone-like cells was aided by their ability to better anchor themselves into the growth environment.
"With our original experiment, we observed that the cells essentially didn't pull on the gel. They adhered to it and were viable, but we did not see bead displacement. They couldn't get a grip," Burdick said. "When we put the cells into a gel where they could degrade the bonds, we saw them spread into the matrix and deform it, displacing the beads."
As an additional test, the researchers synthesized another hydrogel. This one had the same covalent bonds that the stem cells could naturally degrade and spread through but also another type of bond that could form when exposed to light. They let the stem cells spread as before, but at the point the cells would begin to differentiate ? about a week after they were first encapsulated ? the researchers further "set" the gel by exposing it to light, forming new bonds the cells couldn't degrade.
"When we introduced these cross-links so they could no longer degrade the matrix, we saw an increase toward fat-like cells, even after letting them spread," Burdick said. "This further supports the idea that continuous degradation is needed for the cells to sense the material properties of their environment and transduce that into differentiation signals."
Burdick and his colleagues see these results as helping develop a better fundamental understanding of how to engineer tissues using stem cells.
"This is a model system for showing how the microenvironment can influence the fate of the cells," Burdick said.
###
University of Pennsylvania: http://www.upenn.edu/pennnews
Thanks to University of Pennsylvania for this article.
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PHOENIX (Reuters) - A member of the elite U.S. Navy SEALs died and another was injured in a parachute training accident in Arizona, military officials said on Friday.
The man died after being taken to a hospital for injuries sustained in a "free-fall training" accident on Thursday at the U.S. Special Operations Command's Parachute Testing and Training Facility, northeast of Tucson, said Navy spokesman Lieutenant Commander David McKinney.
The injured man remains hospitalized in stable condition, he said.
"I can confirm that a SEAL died yesterday as a result of the accident," McKinney said. "I don't know what happened or what caused the accident."
No other details were available, and the names of the two men were not released. The accident is being investigated.
At this point, if we don?t all know what Brand Beckham is all about, then the joke is on us.
Apparently, former France international Bixente Lizarazu was not paying attention over the last few years as David Beckham frequently treated the LA Galaxy as his little side gig, clearly second fiddle to building and maintaining the iconic brand.
Lizarazu ? if the guy is still in soccer, I can?t find evidence of it ? found someone interested in what he has to say. So he took the opportunity to beat on Beckham a little for jet-setting over to China before next week?s huge Champions League clash; Beckham?s Paris Saint-Germain faces Barcelona in the marquee UEFA semifinal.
What Lizarazu told TF1:
I am sorry, but travelling to China to promote football only 10 days before the most important game of the season is simply not the right way to prepare. No other club would allow one of their players to go on a trip like this. It?s unprofessional.?
Uh, well, actually we know that one club did exactly that. The Galaxy generally acquiesced when Beckham wanted to go to his next royal wedding, modeling gig, Olympic event, etc.
PSG manager Carlo Ancelotti, by the way, wasn?t too worked up about it. He said Beckham returned on Wednesday and missed just one training session.
By: Ronald Arny Corporate Limo Party Is A Classy Service To Make An Impact
Drive in a limousine is immersion in the world of leisure. For corporate limo party there are models of upscale road transport that accommodate different numbers of people. The reason could be any to hire this service but the end is one and it is the comfort of the riders and their exposure to ultimate luxury. It is very common now to have such corporate events in order to celebrate success of a company or an organization. Sense of participation is given to the employees and they become more responsible in their work towards the company. The ride to the venue is very short but it has a significant importance and makes the day.
The best possible transport of the road is available now in state of US. It is a luxurious service that is for the executive class. During the ride they enjoy the features of the vehicles and the expertise of the chauffeurs. Sometimes they are entertained with the complimentary drink on the way to the destination. The riders enjoy the skills of the drivers and the luxury of the cars. They get to the venue of party or meeting in a style and in a fresh mood. Stretched limo and normal limo are present their in the catalogue of the limo service providers. The customers have the liberty to select the car of their choice for the purpose of transportation. The service is used for many other objectives and the customers feel pride to hire it.
The service is a blessing to enjoy the high class that a vehicle could offer in the road transport. The variety of the vehicles and their maintenance is compulsory to attract the customers. In addition to the availability of the resources the dealing of the booking staff and that of the chauffeurs with the guests also play a vital role. The mode of the party sets the theme of the ride and the service providers strictly follow it. For a meeting or a conference a corporate limo service is rather sophisticated and serious in outlook as compare tot that of the celebration of the success.
The interior and exterior of the vehicles are very well maintained to give one hundred percent to the clients and never let them down with the service quality. The drivers are also well aware of the needs of the customers so they act accordingly. The vehicles in the lot have different per hour charges and that are mentioned on the websites of the service providers. The customers can ask for the charges of a particular limo on a specific day and time on the website as well as on the phone.
About the Author: Ronald Arny is the Junior marketing executive at Washington DC Limo Services. You can find more information or ask him any question about Corporate Limo Party or Washington DC Limo Services
Article Originally Published On: http://www.articlesnatch.com
Travel-and-Leisure RSS Feed | RSS feed for this author
Orlando Airport Transportation Tips - Three Things You Should KnowBy: Mike Butter | Mar 29th 2013 - Are you a "Sea World" lover? Will you ever need a shuttle to MCO Airport or top-notch transport to the many exciting, world-class Central Florida attractions?
Your Must-know Guide In Avoiding Vacation MishapsBy: Ruth Larsen | Mar 29th 2013 - Learn to effectively prevent some vacation blunders and have a worry-free holiday trip!
Tags: Denmark WA, holiday accommodation in Denmark WA, accommodation in Denmark WA, holiday accommodation in Denmark
Ideas That Help Make Traveling Less Of A BurdenBy: Dewayne Gates | Mar 29th 2013 - This article will give you advice on how to have a pleasant trip, whether you are traveling to visit relatives, or to go on a cruise. Traveling by trains, boats, cars or planes all share some of the same basic tips.
Tags: coach hire london, coach travel london, coach hire edinburgh, coach hire prices, coach hire quotes...
Tips For Successfully Planning And Making That TripBy: Dewayne Gates | Mar 29th 2013 - An excellent method of exploring new areas and gaining some new insight into the world around us is traveling. Traveling can be very costly and take up a lot of time though. Read on for some advice on how to have the best vacation you can t ...
Tags: corporate coach hire, coach travel for companies, executive coach hire, vip coach hire london, company coach hire...
Acquiring Airport Transfers And Other Tricks For Hassle-free Holiday GetawayBy: Rob | Mar 29th 2013 - It's also smart to book your seat when you get your ticket instead of selecting a seat while you're at the check in counter. So a number of other individuals will be flying that you could get stuck with bad seats or at least, discover that ...
Tags: gold coast airports transfers, airport transfers, shuttle bus
Perfecting Nihongo While Earning A Living In The Land Of The Rising SunBy: Penny Monroe | Mar 29th 2013 - Studying Japanese is the perfect strategy to learn the language of the people from the Land of the Rising Sun.
Tags: beach resort jobs, ski resort jobs, best blog about Japan, studying Japanese in Japan, top holidays in Japan...
Thiruvananthapuram- Evergreen City Of IndiaBy: Gabrieljohn | Mar 29th 2013 - Thiruvananthapuram also called as Trivandrum. The name Trivandrum was re-christened by English. It is the capital city of Kerala. It lies in the west coast of India.
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Shoghi ""on The Mountains Near ShimlaBy: Gabrieljohn | Mar 29th 2013 - Shoghi is a small town near Shimla situated in the state of Himachal Pradesh. Shoghi is at about 13 kilometers beforereaching Shimla on the Ambala Shimla National Highway.
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Pune "" The City Of VirtueBy: Gabrieljohn | Mar 29th 2013 - Famous for the educational institutions and vibrant nightlife, Pune is the second biggest city in the Indian state of Maharashtra. The city welcomes thousands of students from all over India every year.
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Patnitop "" A Piece Of HeavenBy: Gabrieljohn | Mar 29th 2013 - Patnitop or Patni Top, is famous among the tourists as a hilltop tourism location situated in Udhampur district, in the state Jammu and Kashmir , on NH 1A, along the route from, Udhampur to Srinagar.
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Mar. 28, 2013 ? The field of regenerative medicine holds great promise, propelled by greater understanding of how stem cells differentiate themselves into many of the body's different cell types. But clinical applications in the field have been slow to materialize, partially owing to difficulties in replicating the conditions these cells naturally experience.
A team of researchers from the University of Pennsylvania has generated new insight on how a stem cell's environment influences what type of cell a stem cell will become. They have shown that whether human mesenchymal stem cells turn into fat or bone cells depends partially on how well they can "grip" the material they are growing in.
The research was conducted by graduate student Sudhir Khetan and associate professor Jason Burdick, along with professor Christopher Chen, all of the School of Engineering and Applied Science's Department of Bioengineering. Others involved in the study include Murat Guvendiren, Wesley Legant and Daniel Cohen.
Their study was published in the journal Nature Materials.
Much research has been done on how stem cells grow on two-dimensional substrates, but comparatively little work has been done in three dimensions. Three-dimensional environments, or matrices, for stems cells have mostly been treated as simple scaffolding, rather than as a signal that influences the cells' development.
Burdick and his colleagues were interested in how these three-dimensional matrices impact mechanotransduction, which is how the cell takes information about its physical environment and translates that to chemical signaling.
"We're trying to understand how material signals can dictate stem cell response," Burdick said. "Rather than considering the material as an inert structure, it's really guiding stem cell fate and differentiation -- what kind of cells they will turn into."
The mesenchymal stem cells the researchers studied are found in bone marrow and can develop into several cell types: osteoblasts, which are found in bone; chondrocytes, which are found in cartilage; and adipocytes, which are found in fat.
The researchers cultured them in water-swollen polymer networks known as hydrogels, which share some similarities with the environments stem cells naturally grow in. These materials are generally soft and flexible -- contact lenses, for example, are a type of hydrogel -- but can vary in density and stiffness depending on the type and quantity of the bonds between the polymers. In this case, the researchers used covalently cross-linked gels, which contain irreversible chemical bonds.
When seeded on top of two-dimensional covalently cross-linked gels, mesenchymal stem cells spread and pulled on the material differently depending on how stiff it was. Critically, the mechanics guide cell fate, or the type of cells they differentiate it into. A softer environment would produce more fat-like cells and a stiffer environment, where the cells can pull on the gel harder, would produce more bone-like cells.
However, when the researchers put mesenchymal stem cells inside three-dimensional hydrogels of varying stiffness, they didn't see these kinds of changes.
"In most covalently cross-linked gels, the cells can't spread into the matrix because they can't degrade the bonds -- they all become fat cells," Burdick said. "That tells us that in 3D covalent gels the cells don't translate the mechanical information the same way they do in a 2D system."
To test this, the researchers changed the chemistry of their hydrogels so that the polymer chains were connected by a peptide that the cells could naturally degrade. They hypothesized that, as the cells spread, they would be able to get a better grip on their surrounding environment and thus be more likely to turn into bone-like cells.
In order to determine how well the cells were pulling on their environment, the researchers used a technique developed by Chen's lab called 3D traction force microscopy. This technique involves seeding the gel with microscopic beads, then tracking their location before and after a cell is removed.
"Because the gel is elastic and will relax back into its original position when you remove the cells," Chen said, "you can quantify how much the cells are pulling on the gel based on how much and which way it springs back after the cell is removed."
The results showed that the stem cells' differentiation into bone-like cells was aided by their ability to better anchor themselves into the growth environment.
"With our original experiment, we observed that the cells essentially didn't pull on the gel. They adhered to it and were viable, but we did not see bead displacement. They couldn't get a grip," Burdick said. "When we put the cells into a gel where they could degrade the bonds, we saw them spread into the matrix and deform it, displacing the beads."
As an additional test, the researchers synthesized another hydrogel. This one had the same covalent bonds that the stem cells could naturally degrade and spread through but also another type of bond that could form when exposed to light. They let the stem cells spread as before, but at the point the cells would begin to differentiate -- about a week after they were first encapsulated -- the researchers further "set" the gel by exposing it to light, forming new bonds the cells couldn't degrade.
"When we introduced these cross-links so they could no longer degrade the matrix, we saw an increase toward fat-like cells, even after letting them spread," Burdick said. "This further supports the idea that continuous degradation is needed for the cells to sense the material properties of their environment and transduce that into differentiation signals."
Burdick and his colleagues see these results as helping develop a better fundamental understanding of how to engineer tissues using stem cells.
"This is a model system for showing how the microenvironment can influence the fate of the cells," Burdick said.
The research was supported by the National Science Foundation, the National Institutes of Health and the David and Lucile Packard Foundation.
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Story Source:
The above story is reprinted from materials provided by University of Pennsylvania.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Sudhir Khetan, Murat Guvendiren, Wesley R. Legant, Daniel M. Cohen, Christopher S. Chen, Jason A. Burdick. Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nature Materials, 2013; DOI: 10.1038/nmat3586
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Way back in the year 2011, the big box gadget retailer Best Buy surprised us with the launch of dedicated in-store miniature Apple stores, or if you prefer fancier Apple display sections with dedicated sales staff. The move has worked well for both Best Buy and Apple, offering prospective Apple customers and current Mac and iOS users more than one thousand new spots to go check out and pick up the latest gear from Cupertino.
Clearly no longer content playing second fiddle to Apple, Samsung's partnering with Best Buy to do the same, launching before the launch of the Samsung Galaxy S4 at the end of April. According to Geek.com, Best Buy's high traffic stores will be getting the Samsung mini-stores, with staff being told to start clearing out two aisles worth of space next to the popular in-store mobile departments.
Apparently there will be "large Samsung signage" and demonstration stations to show off the features of Samsung products. And like the Apple mini-stores, Best Buy employees will receive special training, though it appears that the entire mobile department staff will be receiving this training instead of select individuals like the Apple sections. If all goes according to plan, Samsung and Best Buy plan to eventually roll the mini-store expansion out to all of Best Buy's locations.
The move signals both Samsung's desire to push forward with their newfound swagger and the acceptance of the largest brick-and-mortar electronics retailer in the United States of the aforementioned swagger. It's worth giving some consideration to how Samsung's store will be adjacent to and staffed by the Best Buy mobile department, where the sales emphasis is almost exclusively on smartphones, with a handful of cellular tablets thrown in for good measure.
Samsung's success in the mobile market has been almost exclusively thanks to their Galaxy S line. Where consumers see Apple as a company that makes desktop computers, laptops, smartphones, and tablets, they see Samsung as televisions and smartphones. Setting up their store inside Best Buy is obviously a step to expand consumer recognition of what Samsung does, but by pairing it with Best Buy's powerful mobile presence they're also acknowledging what customers know and expect of Samsung.
It's also worth considering the benefits in the move for Best Buy. While they'll be losing significant floor space to the Samsung sections, this is a chain that's in the midst of an upheaval of sorts, faltering through a botched bid to take the company private and closing numerous stores over the past year to save costs. No doubt Samsung has paid well for the privilege of getting the same treatment as Apple, and that's money Best Buy desperately needs.
Mar. 27, 2013 ? A team of scientists from the University of California, Los Angeles (UCLA) and Northwestern University has produced 3-D images and videos of a tiny platinum nanoparticle at atomic resolution that reveal new details of defects in nanomaterials that have not been seen before.
Prior to this work, scientists only had flat, two-dimensional images with which to view the arrangement of atoms. The new imaging methodology developed at UCLA and Northwestern will enable researchers to learn more about a material and its properties by viewing atoms from different angles and seeing how they are arranged in three dimensions.
The study will be published March 27 by the journal Nature.
The authors describe being able to see how the atoms of a platinum nanoparticle -- only 10 namometers in diameter -- are arranged in three dimensions. They also identify how the atoms are arranged around defects in the platinum nanoparticle.
Similar to how CT scans of the brain and body are done in a hospital, the scientists took images of a platinum nanoparticle from many different directions and then pieced the images together using a new method that improved the quality of the images.
This novel method is a combination of three techniques: scanning transmission electron microscopy, equally sloped tomography (EST) and three-dimensional Fourier filtering. Compared to conventional CT, the combined method produces much higher quality 3-D images and allows the direct visualization of atoms inside the platinum nanoparticle in three dimensions.
"Visualizing the arrangement of atoms in materials has played an important role in the evolution of modern science and technology," said Jianwei (John) Miao, who led the work. He is a professor of physics and astronomy at UCLA and a researcher with the California NanoSystems Institute at UCLA.
"Our method allows the 3-D imaging of the local structures in materials at atomic resolution, and it is expected to find application in materials sciences, nanoscience, solid state physics and chemistry," he said.
"It turns out that there are details we can only see when we can look at materials in three dimensions," said co-author Laurence D. Marks, a professor of materials science and engineering at Northwestern's McCormick School of Engineering and Applied Science.
"We have had suspicions for a long time that there was more going on than we could see from the flat images we had," Marks said. "This work is the first demonstration that this is true at the atomic scale."
Nanotechnology expert Pulickel M. Ajayan, the Benjamin M. and Mary Greenwood Anderson Professor of Engineering at Rice University complimented the research.
"This is the first instance where the three-dimensional structure of dislocations in nanoparticles has been directly revealed at atomic resolution," Ajayan said. "The elegant work demonstrates the power of electron tomography and leads to possibilities of directly correlating the structure of nanoparticles to properties, all in full 3-D view."
Defects can influence many properties of materials, and a technique for visualizing these structures at atomic resolution could lead to new insights beneficial to researchers in a wide range of fields.
"Much of what we know about how materials work, whether it is a catalyst in an automobile exhaust system or the display on a smartphone, has come from electron microscope images of how the atoms are arranged," Marks said. "This new imaging method will open up the atomic world of nanoparticles."
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Story Source:
The above story is reprinted from materials provided by Northwestern University. The original article was written by Megan Fellman.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Chien-Chun Chen, Chun Zhu, Edward R. White, Chin-Yi Chiu, M. C. Scott, B. C. Regan, Laurence D. Marks, Yu Huang, Jianwei Miao. Three-dimensional imaging of dislocations in a nanoparticle at atomic resolution. Nature, 2013; DOI: 10.1038/nature12009
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
Moffitt researchers analyze HPV vaccination disparities among girls from low-income familiesPublic release date: 27-Mar-2013 [ | E-mail | Share ]
Contact: Kim Polacek kim.polacek@moffitt.org 813-745-7408 H. Lee Moffitt Cancer Center & Research Institute
Pediatricians and private practice physicians have higher vaccination rates; Doctors practicing in multi-specialty settings less likely to vaccinate
Researchers at Moffitt Cancer Center and colleagues at the University of Florida studied health care providers to determine the factors associated with disparities in Human Papillomavirus (HPV) vaccination among girls, ages 9 to 17, from low-income families. They found that physician vaccination strategies and the type of practice play a role in whether or not girls were vaccinated.
The study results were published in the Feb. 1 issue of Cancer.
"The HPV vaccine has made cervical cancer preventable. However, low-income and minority women still experience a higher number of deaths from the disease," said Susan T. Vadaparampil, Ph.D., M.P.H., member of the Health Outcomes and Behavior Program at Moffitt. "There are no-cost HPV vaccination programs available, such as the Vaccines for Children program, to help, but we still find low-income and minority females are less likely to receive the vaccination series."
The HPV vaccine has been recommended for females ages 11 to 26 since 2006. Despite the availability of the vaccine, more than 12,700 women were diagnosed with cervical cancer and 4,290 died from the disease in 2011. As a result, the federal government has included the reduction of HPV infection rates and an increase in HPV vaccination rates in its Healthy People 2020 program.
In order to assess the factors associated with low HPV vaccine rates, the researchers surveyed a random sample of 800 Florida health care providers from the Medicaid Master Provider File. The researchers mailed the providers a 27-item survey that evaluated the characteristics of their practice, their HPV information and knowledge, possible barriers to HPV vaccination, and their vaccine recommendation and strategy practices.
The researchers found that:
Family physicians had a lower patient HPV vaccination prevalence than pediatricians.
Physicians in multi-specialty practice were less likely to vaccinate than those in single specialty practice.
Providers using two or more strategies to ensure HPV vaccination were more likely to vaccinate than those with no strategies.
The researchers also found that providers of the no-cost Vaccine for Children program were more likely to vaccinate than those who did not participate in the program. Also, physicians who reported caring for minority groups had higher vaccination averages than those caring for non-minorities.
"This research helps us identify key ways in which we can target future provider interventions," Vadaparampil said. "Our next steps will be to develop interventions that target the providers and settings where vaccination rates were lowest."
Given that black and Hispanic women have higher rates of cervical cancer when compared to their white counterparts, these physicians may be more sensitized to the importance of vaccination against cervical cancer, said the researchers.
The finding they called "interesting" was that vaccination rates were relatively low in light of a patient's eligibility for free vaccination through the Vaccine for Children program. Other factors may have impeded vaccination, they suggested, such as disruption of provider vaccination supply or patient refusal.
"Since all patients of all physicians surveyed were eligible for free vaccination due to their participation in the Florida Medicaid program, our findings suggest that cost may not be the only barrier to vaccination," explained Teri Malo, Ph.D., M.P.H., applied research scientist in the Health Outcomes and Behavior Program at Moffitt.
"Our findings suggest that HPV vaccination disparities among low-income females, even in the absence of cost, require targeted intervention to increase vaccination rates among underserved populations," concluded the researchers. The intervention may focus on family physicians and specialty physicians who practice in non-private and multi-specialty settings who see primarily non-Hispanic white patients and use no strategies to ensure vaccination completion.
###
Funding for this study included grants from the National Institutes of Health (R01AI076440-01; K01AA018255) and University of Florida-Moffitt Cancer Center Collaborative Initiative Grant (UF09035).
About Moffitt Cancer Center
Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.
Media release by Florida Science Communications
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Moffitt researchers analyze HPV vaccination disparities among girls from low-income familiesPublic release date: 27-Mar-2013 [ | E-mail | Share ]
Contact: Kim Polacek kim.polacek@moffitt.org 813-745-7408 H. Lee Moffitt Cancer Center & Research Institute
Pediatricians and private practice physicians have higher vaccination rates; Doctors practicing in multi-specialty settings less likely to vaccinate
Researchers at Moffitt Cancer Center and colleagues at the University of Florida studied health care providers to determine the factors associated with disparities in Human Papillomavirus (HPV) vaccination among girls, ages 9 to 17, from low-income families. They found that physician vaccination strategies and the type of practice play a role in whether or not girls were vaccinated.
The study results were published in the Feb. 1 issue of Cancer.
"The HPV vaccine has made cervical cancer preventable. However, low-income and minority women still experience a higher number of deaths from the disease," said Susan T. Vadaparampil, Ph.D., M.P.H., member of the Health Outcomes and Behavior Program at Moffitt. "There are no-cost HPV vaccination programs available, such as the Vaccines for Children program, to help, but we still find low-income and minority females are less likely to receive the vaccination series."
The HPV vaccine has been recommended for females ages 11 to 26 since 2006. Despite the availability of the vaccine, more than 12,700 women were diagnosed with cervical cancer and 4,290 died from the disease in 2011. As a result, the federal government has included the reduction of HPV infection rates and an increase in HPV vaccination rates in its Healthy People 2020 program.
In order to assess the factors associated with low HPV vaccine rates, the researchers surveyed a random sample of 800 Florida health care providers from the Medicaid Master Provider File. The researchers mailed the providers a 27-item survey that evaluated the characteristics of their practice, their HPV information and knowledge, possible barriers to HPV vaccination, and their vaccine recommendation and strategy practices.
The researchers found that:
Family physicians had a lower patient HPV vaccination prevalence than pediatricians.
Physicians in multi-specialty practice were less likely to vaccinate than those in single specialty practice.
Providers using two or more strategies to ensure HPV vaccination were more likely to vaccinate than those with no strategies.
The researchers also found that providers of the no-cost Vaccine for Children program were more likely to vaccinate than those who did not participate in the program. Also, physicians who reported caring for minority groups had higher vaccination averages than those caring for non-minorities.
"This research helps us identify key ways in which we can target future provider interventions," Vadaparampil said. "Our next steps will be to develop interventions that target the providers and settings where vaccination rates were lowest."
Given that black and Hispanic women have higher rates of cervical cancer when compared to their white counterparts, these physicians may be more sensitized to the importance of vaccination against cervical cancer, said the researchers.
The finding they called "interesting" was that vaccination rates were relatively low in light of a patient's eligibility for free vaccination through the Vaccine for Children program. Other factors may have impeded vaccination, they suggested, such as disruption of provider vaccination supply or patient refusal.
"Since all patients of all physicians surveyed were eligible for free vaccination due to their participation in the Florida Medicaid program, our findings suggest that cost may not be the only barrier to vaccination," explained Teri Malo, Ph.D., M.P.H., applied research scientist in the Health Outcomes and Behavior Program at Moffitt.
"Our findings suggest that HPV vaccination disparities among low-income females, even in the absence of cost, require targeted intervention to increase vaccination rates among underserved populations," concluded the researchers. The intervention may focus on family physicians and specialty physicians who practice in non-private and multi-specialty settings who see primarily non-Hispanic white patients and use no strategies to ensure vaccination completion.
###
Funding for this study included grants from the National Institutes of Health (R01AI076440-01; K01AA018255) and University of Florida-Moffitt Cancer Center Collaborative Initiative Grant (UF09035).
About Moffitt Cancer Center
Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.
Media release by Florida Science Communications
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Educators in a Texas school district will soon be permitted to carry guns in the classroom, assuming they get approval from the school superintendent, pass a training course and obtain a concealed-handgun license.
The Levelland Independent School District, which is about 30 miles west of Lubbock, instituted the policy in response to last year's deadly shooting at Sandy Hook Elementary School in Newtown, Conn., as well as the shooting at the Aurora, Colo., movie theater.
"How do you describe a tragedy like that? It's devastating," Levelland ISD Superintendant Kelly Baggett told ABC News, referencing the Sandy Hook massacre. "It absolutely instilled fear in all of us and made us take a hard look at where we are with our safety and security.
WATCH VIDEO: District Approves Gun-Toting Teachers
Baggett said the Levelland ISD School board voted Thursday for the policy change allowing teachers to carry guns only after extensive research and a series of meetings.
"Not every teacher in Levelland is going to carry a gun to campus," Baggett said. "It will be certain individuals that I and the school approve. The training is paramount. It's absolutely the most important thing."
Under the new policy, teachers would first need to obtain a concealed-handgun license and pass a gun-training course. The exact nature of the training course isn't yet known, but the Texas State Legislature is considering legislation to establish standards for firearms training for public school employees.
Levelland would not be the first Texas school district to arm employees. David Thweatt, superintendent for Harrold Independent School District in north-central Texas, told ABC News his school board voted unanimously to arm school employees after the 2007 Virginia Tech shooting, which he says was a wakeup call.
"The idea that we have moved into a society that the police have to do everything is ridiculous," Thweatt said. "Active shooters know where they are going. If your school is known to have a policy in place where people are protecting children with deadly force, they are not coming to your school."
Thweatt says the training his employees received involved lots of time spent on accuracy and shooting, while the other component involved strategies for clearing and securing rooms. It took about a week to complete.
Baggett of the Levelland district said Texas Law does not allow handguns on public school property, but a loophole exists in the penal code that says that a school board can authorize concealed handguns with the approval of a school attorney. The Levelland ISD has about 3,000 students and 485 staff members spread across eight campuses and, Baggett says, he hopes to arm two employees per campus.
Baggett says the parental and community response to the new policy arrangement has been mostly positive. "For the most part, we are getting very, very nice compliments and encouragement and positive remarks from our community members and they are applauding us for taking a stand and doing what we are doing," he said.
Baggett hopes to get those he chooses to arm trained this summer and have them ready and on campus before the start of the 2013-2014 school year.
"I have reservations about putting weapons in employees' hands," he said. "We are trained educators and it's a shame that it's gotten to the point in society that we are having to arm our school employees to protect their kids. But my philosophy is I want to do everything I can to protect our kids."
Mar. 27, 2013 ? An international team of astronomers, including researchers from the Max Planck Institute for Radio Astronomy and from the University of Cologne, successfully identified two titanium oxides in the extended atmosphere around a giant star. The object VY Canis Major is one of the largest stars in the known universe and close to the end of its life. The detection was made using telescope arrays in the USA and in France.
The discovery was made in the course of a study of a spectacular star, VY Canis Majoris or VY CMa for short, which is a variable star located in the constellation Canis Major (Greater Dog). "VY CMa is not an ordinary star, it is one of the largest stars known, and it is close the end of its life," says Tomasz Kami?ski from the Max Planck Institute for Radio Astronomy (MPIfR). In fact, with a size of about one to two thousand times that of the Sun, it could extend out to the orbit of Saturn if it were placed in the centre of our Solar System.
The star ejects large quantities of material which forms a dusty nebula. It becomes visible because of the small dust particles that form around it which reflect light from the central star. The complexity of this nebula has been puzzling astronomers for decades. It has been formed as a result of stellar wind, but it is not understood well why it is so far from having a spherical shape.
Neither is known what physical process blows the wind, i.e. what lifts the material up from the stellar surface and makes it expand. "The fate of VY CMa is to explode as a supernova, but it is not known exactly when it will happen," adds Karl Menten, head of the "Millimetre and Submillimetre Astronomy" Department at MPIfR.
Observations at different wavelengths provide different pieces of information which is characteristic for atomic and molecular gas and from which physical properties of an astronomical object can be derived. Each molecule has a characteristic set of lines, something like a 'bar code', that allows to identify what molecules exist in the nebula.
"Emission at short radio wavelengths, in so-called submillimetre waves, is particularly useful for such studies of molecules," says Sandra Br?nken from the University of Cologne. "The identification of molecules is easier and usually a larger abundance of molecules can be observed than at other parts of the electromagnetic spectrum."
The research team observed TiO and TiO2 for the first time at radio wavelengths. In fact, titanium dioxide has been seen in space unambiguously for the first time. It is known from every-day life as the main component of the commercially most important white pigment (known by painters as "titanium white") or as an ingredient in sunscreens. It is also quite possible that the reader consumed some amounts of it as it is used to colour food (coded as E171 in the labels).
However, stars, especially the coolest of them, are expected to eject large quantities of titanium oxides, which, according to theory, form at relatively high temperatures close to the star. "They tend to cluster together to form dust particles visible in the optical or in the infrared," says Nimesh Patel from the Harvard-Smithsonian Center for Astrophysics. "And the catalytic properties of TiO2 may influence the chemical processes taking place on these dust particles, which are very important for forming larger molecules in space," adds Holger M?ller from the University of Cologne.
Absorption features of TiO have been known from spectra in the visible region for more than a hundred years. In fact, these features are used in part to classify some types of stars with low surface temperatures (M- and S-type stars). The pulsation of Mira stars, one specific class of variable stars, is thought to be caused by titanium oxide. Mira stars, supergiant variable stars in a late stage of their evolution, are named after their prototype star "Mira" (the wonderful) in the constellation of Cetus (the 'sea monster' or the 'whale').
The observations of TiO and TiO2 show that the two molecules are easily formed around VY CMa at a location that is more or less as predicted by theory. It seems, however, that some portion of those molecules avoid forming dust and are observable as gas phase species. Another possibility is that the dust is destroyed in the nebula and releases fresh TiO molecules back to the gas. The latter scenario is quite likely as parts of the wind in VY CMa seem to collide with each other.
The new detections at submillimetre wavelengths are particularly important because they allow studying the process of dust formation. Also, at optical wavelengths, the radiation emitted by the molecules is scattered by dust present in the extended nebula which blurs the picture, while this effect is negligible at radio wavelengths allowing for more precise measurements.
The discoveries of TiO and TiO2 in the spectrum of VY CMa have been made with the Submillimetre Array (SMA), a radio interferometer located at Hawaii, USA. Because the instrument combines eight antennas which worked together as one big telescope 226-meters in size, astronomers were able to make observations at unprecedented sensitivity and angular resolution. A confirmation of the new detections was successively made later with the IRAM Plateau de Bure Interferometer (PdBI) located in the French Alps.
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The above story is reprinted from materials provided by Max-Planck-Gesellschaft.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
T. Kami?ski, C. A. Gottlieb, K. M. Menten, N. A. Patel, K. H. Young, S. Br?nken, H. S. P. M?ller, M. C. McCarthy, J. M. Winters, L. Decin. Pure rotational spectra of TiO and TiO2in VY Canis Majoris. Astronomy & Astrophysics, 2013; 551: A113 DOI: 10.1051/0004-6361/201220290
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
LONDON (AP) - The World Anti-Doping Agency has defended its test for human growth hormone and accused the NFL players union of being "extremist" for questioning its validity.
WADA director general David Howman tells The Associated Press the test for HGH was endorsed by the Court of Arbitration for Sport in its ruling Tuesday in the case of an Estonian cross-country skier.
The court lifted the three-year suspension imposed by the International Ski Federation on two-time Olympic cross-country champion Andrus Veerpalu for use of HGH, citing "procedural flaws." But CAS said it believed Veerpalu did take HGH and backed the testing method.
Howman says "there is no question as to the validity of the test."
The NFL players union said the CAS ruling "validates the players' demands for scientific validity, full due process rights, and a transparent system."
Howman says "I would expect the players association to take a stance which is extremist which is the way they've operated the last few years."
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Developing our sense of smellPublic release date: 25-Mar-2013 [ | E-mail | Share ]
Contact: Deborah Williams-Hedges debwms@caltech.edu 626-395-3227 California Institute of Technology
Caltech biologists pinpoint the origin of olfactory nerve cells
PASADENA, Calif.When our noses pick up a scent, whether the aroma of a sweet rose or the sweat of a stranger at the gym, two types of sensory neurons are at work in sensing that odor or pheromone. These sensory neurons are particularly interesting because they are the only neurons in our bodies that regenerate throughout adult lifeas some of our olfactory neurons die, they are soon replaced by newborns. Just where those neurons come from in the first place has long perplexed developmental biologists.
Previous hypotheses about the origin of these olfactory nerve cells have given credit to embryonic cells that develop into skin or the central nervous system, where ear and eye sensory neurons, respectively, are thought to originate. But biologists at the California Institute of Technology (Caltech) have now found that neural-crest stem cellsmultipotent, migratory cells unique to vertebrates that give rise to many structures in the body such as facial bones and smooth musclealso play a key role in building olfactory sensory neurons in the nose.
"Olfactory neurons have long been thought to be solely derived from a thickened portion of the ectoderm; our results directly refute that concept," says Marianne Bronner, the Albert Billings Ruddock Professor of Biology at Caltech and corresponding author of a paper published in the journal eLIFE on March 19 that outlines the findings.
The two main types of sensory neurons in the olfactory system are ciliated neurons, which detect volatile scents, and microvillous neurons, which usually sense pheromones. Both of these types are found in the tissue lining the inside of the nasal cavity and transmit sensory information to the central nervous system for processing.
In the new study, the researchers showed that during embryonic development, neural-crest stem cells differentiate into the microvillous neurons, which had long been assumed to arise from the same source as the odor-sensing ciliated neurons. Moreover, they demonstrated that different factors are necessary for the development of these two types of neurons. By eliminating a gene called Sox10, they were able to show that formation of microvillous neurons is blocked whereas ciliated neurons are unaffected.
They made this discovery by studying the development of the olfactory system in zebrafisha useful model organism for developmental biology studies due to the optical clarity of the free-swimming embryo. Understanding the origins of olfactory neurons and the process of neuron formation is important for developing therapeutic applications for conditions like anosmia, or the inability to smell, says Bronner.
"A key question in developmental biologythe extent of neural-crest stem cell contribution to the olfactory systemhas been addressed in our paper by multiple lines of experimentation," says Ankur Saxena, a postdoctoral scholar in Bronner's laboratory and lead author of the study. "Olfactory neurons are unique in their renewal capacity across species, so by learning how they form, we may gain insights into how neurons in general can be induced to differentiate or regenerate. That knowledge, in turn, may provide new avenues for pursuing treatment of neurological disorders or injury in humans."
Next, the researchers will examine what other genes, in addition to Sox10, play a role in the process by which neural-crest stem cells differentiate into microvillous neurons. They also plan to look at whether or not neural-crest cells give rise to new microvillous neurons during olfactory regeneration that happens after the embryonic stage of development.
###
Funding for the research outlined in the eLIFE paper, "Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish," was provided by the National Institutes of Health and the Gordon Ross Postdoctoral Fellowship. Brian N. Peng, a former undergraduate student (BS '12) at Caltech, also contributed to the study. A new open-access, high-impact journal, eLIFE is backed by three of the most prestigious biomedical research funders in the world: the Howard Hughes Medical Institute, the Max Planck Society, and the Wellcome Trust.
Written by Katie Neith
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Developing our sense of smellPublic release date: 25-Mar-2013 [ | E-mail | Share ]
Contact: Deborah Williams-Hedges debwms@caltech.edu 626-395-3227 California Institute of Technology
Caltech biologists pinpoint the origin of olfactory nerve cells
PASADENA, Calif.When our noses pick up a scent, whether the aroma of a sweet rose or the sweat of a stranger at the gym, two types of sensory neurons are at work in sensing that odor or pheromone. These sensory neurons are particularly interesting because they are the only neurons in our bodies that regenerate throughout adult lifeas some of our olfactory neurons die, they are soon replaced by newborns. Just where those neurons come from in the first place has long perplexed developmental biologists.
Previous hypotheses about the origin of these olfactory nerve cells have given credit to embryonic cells that develop into skin or the central nervous system, where ear and eye sensory neurons, respectively, are thought to originate. But biologists at the California Institute of Technology (Caltech) have now found that neural-crest stem cellsmultipotent, migratory cells unique to vertebrates that give rise to many structures in the body such as facial bones and smooth musclealso play a key role in building olfactory sensory neurons in the nose.
"Olfactory neurons have long been thought to be solely derived from a thickened portion of the ectoderm; our results directly refute that concept," says Marianne Bronner, the Albert Billings Ruddock Professor of Biology at Caltech and corresponding author of a paper published in the journal eLIFE on March 19 that outlines the findings.
The two main types of sensory neurons in the olfactory system are ciliated neurons, which detect volatile scents, and microvillous neurons, which usually sense pheromones. Both of these types are found in the tissue lining the inside of the nasal cavity and transmit sensory information to the central nervous system for processing.
In the new study, the researchers showed that during embryonic development, neural-crest stem cells differentiate into the microvillous neurons, which had long been assumed to arise from the same source as the odor-sensing ciliated neurons. Moreover, they demonstrated that different factors are necessary for the development of these two types of neurons. By eliminating a gene called Sox10, they were able to show that formation of microvillous neurons is blocked whereas ciliated neurons are unaffected.
They made this discovery by studying the development of the olfactory system in zebrafisha useful model organism for developmental biology studies due to the optical clarity of the free-swimming embryo. Understanding the origins of olfactory neurons and the process of neuron formation is important for developing therapeutic applications for conditions like anosmia, or the inability to smell, says Bronner.
"A key question in developmental biologythe extent of neural-crest stem cell contribution to the olfactory systemhas been addressed in our paper by multiple lines of experimentation," says Ankur Saxena, a postdoctoral scholar in Bronner's laboratory and lead author of the study. "Olfactory neurons are unique in their renewal capacity across species, so by learning how they form, we may gain insights into how neurons in general can be induced to differentiate or regenerate. That knowledge, in turn, may provide new avenues for pursuing treatment of neurological disorders or injury in humans."
Next, the researchers will examine what other genes, in addition to Sox10, play a role in the process by which neural-crest stem cells differentiate into microvillous neurons. They also plan to look at whether or not neural-crest cells give rise to new microvillous neurons during olfactory regeneration that happens after the embryonic stage of development.
###
Funding for the research outlined in the eLIFE paper, "Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish," was provided by the National Institutes of Health and the Gordon Ross Postdoctoral Fellowship. Brian N. Peng, a former undergraduate student (BS '12) at Caltech, also contributed to the study. A new open-access, high-impact journal, eLIFE is backed by three of the most prestigious biomedical research funders in the world: the Howard Hughes Medical Institute, the Max Planck Society, and the Wellcome Trust.
Written by Katie Neith
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Looking at four great apps to make tracking or taking care of one's health a breeze.
An iPhone or iPad can be used for many different and fun purposes, it can also be used to help those in need of medical assistance. I don?t just mean in terms of being able to call 911, either. Here?s our look at four great apps that help assist users in some way, either through providing medical information or reminders just when they need it most.
RxmindMe Prescrption/Medicine Reminder and Pill Tracker It?s not the newest of apps but RxmindMe is still a great one. The app is a prescription reminder service that should help keep track of all the medication that some people need to take. Nine different types of reminders mean it doesn?t matter if the medication needs to be taken every hour or even just on a particular day of the month, this app has its users covered. Further details mean it?s possible to track quantities, export information, take photos of the medication and search extensively for any FDA approved drug. Impressive going for an app that?s free to use.
FREE!
iPhone App - Designed for the iPhone, compatible with the iPad Released: 2010-09-27 :: Category: Medical
iPharmacy Want to know everything about a type of medication, from dosage and side effects to how it interacts with other drugs? iPharmacy should have you covered. The app does a little bit of everything with simple reminders, an encyclopaedia of drugs and relevant information about them, as well as the means in which to find the cheapest pharmacy to buy them. iPharmacy proves a handy guide to all the latest recalls and alerts too, keeping its users safe.
FREE!
iPhone App - Designed for the iPhone, compatible with the iPad Released: 2010-06-16 :: Category: Medical
Glucose Buddy For the diabetic, it?s vital to keep track of various important information such as glucose levels, carbohydrate consumption and insulin dosage. Glucose Buddy does all that and offers syncing options to keep such things safe. Graphs and logbooks make tracking everything a breeze, and safe and easy to demonstrate to a doctor when attending a regular check up. There?s integration with CalorieTrack, too, making it easier to log food and exercise details.
FREE!
iPhone App - Designed for the iPhone, compatible with the iPad Released: 2008-10-28 :: Category: Medical
iTriage While it?s ideal to go visit a doctor with concerns, it?s not always possible or convenient. iTriage offers advice for many symptoms, diseases and conditions, helping its users figure out whether they need to go visit someone or whether there isn?t a concern. Alongside such information, there are details on where to find the nearest ER or relevant clinic, as well as emergency hotlines and even an average wait time for certain facilities.
FREE!
+ Universal App - Designed for iPhone and iPad Released: 2009-02-18 :: Category: Healthcare & Fitness Posted in: Blog, Favorite 4
Tagged with: favorite 4, favorite four, Glucose Buddy, iPharmacy, itriage, Medical Aid, Medical Assistance, RxmindMe Prescription/Medicine Reminder and Pill Tracker
Review disclosure: note that the product reviewed on this page may have been provided to us by the developer for the purposes of this review. Note that if the developer provides the product or not, this does not impact the review or score.
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